Fatty Acid Synthesis (Part 10 of 12) – Excessive Alcohol Consumption and Fatty Liver

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Moof’s Medical Biochemistry Video Course: http://moof-university.thinkific.com/courses/medical-biochemistry-for-usmle-step-1-exam

In the final video on fatty acid synthesis, I discuss how excessive consumption of alcohol (ethanol) affects fatty acid synthesis and how it can specifically cause fatty liver, which can lead to liver failure.

Ethanol cannot be excreted by our bodies and thus must be metabolized to acetaldehyde and to acetate. These oxidative processes result in an accumulation of NADH. The high NADH concentration and high NADH/NAD+ ratio leads to the inhibition of beta oxidation and the activation of fatty acid synthesis in our liver.

Fatty acids and triglycerides accumulate in our liver (fatty liver), and this can be detrimental as this excess fat can lead to liver cell death, which can lead to liver failure, which can lead to death. This is just one of the ways chronic excessive alcohol consumption can be harmful.

For a suggested viewing order of the videos, information on tutoring, and an opportunity to support me with donations, visit my website at the link below.

Moof University Website: www.MoofUniversity.com

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