Binge alcohol consumption represents a significant public health crisis in the U.S., accounting for more than 178,000 reported deaths across the country in 2021. Wisconsin consistently ranks as the top state in the nation for binge drinking and has seen a disturbing upward trend in alcohol-related deaths over the past decade. In 2020, more than 1,500 deaths in Wisconsin were attributed to alcohol, with causes ranging from liver disease and alcohol poisoning to accidents related to alcohol impairment. Despite the devastating effects of both at the individual and public health level, very few effective treatment options exist for alcohol use disorder. And in a small percentage of cases where individuals with alcohol use disorder receive treatment, relapse is common. Dismal recovery rates for people with alcohol use disorder highlight the need for better therapeutic options, starting with improving our understanding of the cellular and molecular processes that underly relapse. In this AHW-funded project, researchers from the Medical College of Wisconsin are leveraging cutting-edge science to chronicle how binge alcohol withdrawal modifies the molecular landscape and contributes to relapse behaviors. Their research aims to contribute to the development of effective, evidence-based interventions to reduce alcohol misuse in Wisconsin and worldwide.
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